A friend of mine has QD on his 416Rigby and has two different scope setups for two different loads - plains game and dangerous game.
I haven't been to Africa but shoot informal competition and have QD (Warne) on my 458WM - one scope for normal loads and another for cast loads. An NECG rear ghost ring sight spends most time on the rifle. If I were to hunt I Africa, I'd take the 458 with scope + ghost ring as a back-up.
I've never had any issues with the Warne QDs and they always maintain the sight settings. I'm always swapping the scopes and GR sights over so they've had plenty of use.
