I've used both the 250 Interlock and the 250 GameKing on a few moose including one at a bit beyond 387 which absorbed one of each. They landed about 6" apart in the meaty part of the shoulders. The Gameking penetrated all the way; the Interlock was lodged in the meat near the far side. (with 340 Weatherby)

Sometimes, the air you 'let in'matters less than the air you 'let out'.