I use Retumbo in my 30X378 for years with 180's and have never had a problem. I also tried it in my Pre 64 264 Westerner but found better accuracy with Ramshot Magnum and RL-33
Dusty,
Would you mind sharing the load for the 180 grain bullet loaded into a 30-378?
The Retumbo bottle lists a 180 grain bullet over 113 grains of Retumbo in the 30-378. My ballistics program indicates that the pressure is close to 70,000 PSI, but not quite there. It indicates that's a safe load.