Back when I couldn't get NPTs or bonded bullets during the most recent past unpleasantness, I switched to the using the ELD-X out of the 6.5 CM on my annual 1 or 2 cow elk wanderings.
What I would do is make the effort to avoid big bones and go for mid-to-high lung shots. Never a problem, and the furthest I ever had to look for one was at most 40 yards. The majority were downed far closer than that. All were pass through shots.
I agree with longarm - they should work very well on typically sized deer and antelope. In fact, when the stash of .257 110 gr. NABs are gone, I'll be switching to the ELD-X.
No experience using them on plains game in Africa. For them I'm an A-Frame groopie.
