Any of the calibers mentioned will work, but if I was going to take 500 yard shots, which I do not as you will sooner or later break a leg at that range, then the 7 mag with 160 gr. Noslers would be my choice.
My favorite Mule Deer rifles are the 270 WCF and most years I use my Win. 94 SRC in 25-35 just out of nostalgia. I limit my shots to 150 yards broadside with the 25-35 and it kills very well..I have had to let a lot of really big bucks walk when hunting with the 25-35 because they were out of range. If I want to see a monster I just carry that gun and they show up. If I take the 270 I never see'em it seems!!
