Even with the same bullet weight and muzzle velocity different powders produce different pressure-time curves. This means a particular powder may not be well suited to the operating cycle of a given semi auto.

For example, if you're going to shoot 168 grain match bullets out of an M1A you need to be looking at 4895 or something pretty close to it. If the powder is much slower than that it will produce excessive port pressure and batter the action.