I've used them on coyotes to good effect though with larger chamberings-22-250AI and 223WSSM.
Here is a pic of a coyote that almost needed a finisher as the A-max blew up in his shoulder and didn't make it into the boiler.
I was glad that after walking up to him and pondering a bit he stopped breathing just before I added a second.
This experience didn't sour me on them at all but does show they aren't that hard a bullet.
In my experience a great varmint.
[Linked Image]
[Linked Image]