I went to the range today to try out a Ruger BH 45colt I just picked up.
I brought along a box of Mag Tec 250grn cowboy loads and a box of Buffalo Bore 325grn.
The MT loads were easy shooting, fairly accurate(I'm not an accomplished pistol shot!), and I have no doubt, plenty capable of taking deer at any range I could safley hit one at.
The BB loads were stout. 325grn at a claimed 1325fps. After the third round I caught myself flinching and had to slow down and concentrate! I imagine these things would put a loooong wide hole in what ever you shoot.