Ray,
Am I missing something with 5744?
I understand 5744 was developed specifically for large case capacity big bores as a high bulk fast burning powder for reduced loads, negating the need for fillers and it isn't position sensitive. IIRC, Western Powders used the .416 Rigby as the platform for development.
Use of a filler might give you a tad bit better consistency, but isn't necessary.
David