BobinNH offered some sage advice. I like that part about hitting a basketball at 400 yards in five seconds. Nice analogy.

Ingwe - wow - what a monster buck! Awesome.

Jeff_O - I do most of my mule deer hunting with a .25-06 700 CDL and a fixed 6x Leupold. Over the past six years it's given me five mule deer, from 30 yards to an honest 400 yards. Light enough to pack easily up and down the mountains. Handy enough for quick shots. Accurate enough for longish range shooting.

Given your rifle inventory, I'd likely just grab the .30-06, and make sure to burn a bunch of rounds through it this coming year, also making sure to be in great physical condition for a potentially tough hunt.

Regards, Guy