The 375 Ruger is quite popular up here and ammo doesn't seem to be a problem.
As for Africa, how many folks take Weatherbys, Lazzeronis, Dakotas or wildcats like the 416 Taylor or 475 Turnbull, or even the 45-70 and never give a thought to ammo availability?

Phil Shoemaker
Alaska Master Guide,
Alaska Hunter Ed Instructor
FAA Master pilot
www.grizzlyskinsofalaska.com

Anyone who claims the 30-06 is not effective has either not used one, or else is unwittingly commenting on their marksmanship.