What twist barrel ????? In my opinion this chambering is a waste of time and barrel in a slow twist (1-10" 1-14").
In a 1-8" for the heavy VLD bullet's is where it would be at it's best, even then it is too much of a good thing as barrel life will be shorter than need be. In my experience a 22-250AI is about max capacity for a 22 cal. bore.