Mak,
I've used the 225gr Accubond in my .338 Win. Mag for quite a number of elk and a caribou and never had any issues with the bullet performing as it should. I wouldn't hesitate to take that cartridge with that bullet to Africa for plains game. When I went to Africa, I took the .338, but had it loaded with 250gr A-frames instead since I anticipated using it for Eland. Didn't get a chance to use it on eland but it worked just fine on all the other plains game and I'm sure the 225 AB will work well also.