I run a 6X42 on my GFY twins. The 7-08 (yellow) has the LR reticle and is primarily set up for deer hunting. My 22-250 has M1's on both elevation and windage. The 22-250 is a true "do all" setup. Fun shooting steel, gophers, prairie dogs, coyotes, deer hunting etc. Only disadvantage to the M1 setup is the windage knob hits my wrist a lot when carrying, and it tends to beat up the center console of my vehicle.
Hits to 400yds are no trick with either rig. They both work great.
If you go turrets for both, take a gander at the CDS. Little more low profile.
I am not a gunwriter, but the Bruins did lose.
Travis