I just bought my first 25-06 a month ago so have no hunting experience with it yet.
The last moose I shot with a .270 was hit 4 times in the chest with 150 Nosler Ptns. If I hadn't heard the last shot strike the animal I would have thought they were all misses. The bull walked off as though unhurt. When found he had only gone about 10 or 15 yards.
I've killed a number of moose with the .270 and up close this caliber works fine. At extended range it starts to poop out. Now I shoot a .338 WM for the "just in case" shots.
I'm not an elk hunter but I would not recommend a 25-06 for someone not living/working close to the hunting area. Just my opinion for whatever its worth.