If you're still reading, check out the 6mm BR. Very efficient and will handle multiple, long shot strings without worry. Barrel should last 3-4 thousand rounds, or more.
I have looked at a Savage 12 LRPV in that caliber. I'm not sure I like the stock-prefer wood really but, I won't discount it. I suppose other than the 6PPC it's right up there in accuracy and with the larger barrel not the heat up problems.
Make no mistake, the 257 Weatherby is a fine cartridge and about the only one I'd pick. Factory ammo is most expensive, I've found out.