If you want the least amount of meat loss, shoot them where there is the least amount of meat. Duh! Head shots are a little tough on trophies, but that was not mentioned. I have found that a 168 TSX at 30-06 velocities through the shoulders at up to 225 yards, I lost very little meat. Eat almost right to the bullet hole. And I have only had one deer go more than two steps.
