The thing I like about the barnes is the expansion/speed rate compared to the E-tip or the GMX bullets... I have had nothing but good luck with TTSX in all the calibers I have ever tried them in... My .280AI dumped a mulie in WY this year at 615 and went through double lung and was bleeding excellent, not knowing 100% how much damage the first shot had done, and he was just standing there. I sent a second shot at 598 and took both shoulders out and found the bullet just sticking through the skin as we quartered him out on the top of the mountain... The bullet was a 140TTSX running 3280 and opened up 85-90 percent and held 139.6grs of weight after I got it cleaned up and back to the bench scale.... LOVE my barnes!!!