They all work,it's just a matter of matching the bullet to the game.
For instance,I finished developing a load for a Springfield 1903 .30-06 and a Leupold 3x. The load is 55.0 grs RL-19,Fed 210 Match and a 220 gr Hornady RN velocity is 2371 fps average. Is this load a for antelope,no,it'll work,but it's more suitable for elk,moose and bear in the brush. Have it sighted in dead on @ 100 yds. This is my back-up rifle for my bear hunt in Arizona this November.
One more thing,we can argue about this bullet or rifle or scope or cartridge etc.. it don't matter,use what you want and go forth and kill critters. The best thing anyone can do is PRACTICE! PRACTICE! PRACTICE!