Quite frankly, in a 5-shot revolver, the .45 Colt can be loaded to near .454 pressures. That said, I can see no reason to load it that hot. Even the ammo manufacturers aren't loading it any longer to its SAAMI max (65,000 psi). The .454 buys you some more range, but long range isn't my objective while handgun hunting.
Agree 100%. I keep my 454 loads to pushing a 335 cp to 1350ish. Don't need any more than that for what I'm doing.
