No problem with the load per se. As others have said, lopes are pretty easy to get a bullet through.
As others have noted, the wind is a factor, and often drives my bullet selection more so than the critter for not only lopes, but mule deer as well on the plains.
One more thing to consider: while they don't offer much resistance for a bullet, they are one of the toughest little sumbitches if you hit them wrong. If you want to switch loads, pick one that can get through a shoulder.
