My wife has a S&W 640 in .357, weighs 23 oz. It's a hand full with .357's, we keep +P's in it. Friend has an LCR .357, he carries +P's also. Just too much blast and buck in a revolver that small, IMHO it is better to get back on target quicker.
Exactly why the SP-101 makes so much sense. I love mine, easy to shoot.