I don't normally hunt with a rifle because I'm in a shotgun zone in MN but when I do, I use my Ruger M77 7mm Mag:
That is topped with a Leupold VXII 3x9-40 and shooting 140 grain accubonds.
I will have to admit though that my Ruger M77 22-250 is my all time favorite gun. That thing never ceases to amaze.