I competed in handgun metallic silhouette for a few years.

I shot 357 mag and then immediately switched to 44 mag.
I had no problems hitting/downing rams with the 44 mag.
I hit them just as well with the 357 mag but knocking them down was iffy.

I found both with good loads capable of surprising accuracy at 100 or 200 meters.

About the time l quit metallic shooting l was usually good for 36/40.
The target l missed the most often was the #&*% turkey at 150 m.
My match handgun was a stainless Super Blackhawk Ruger sa 10" bbl open sites.