As has been pointed out, based upon my experience (which is admittedly limited) that is likely a hot load I'd not make hotter.
Check out the Nosler data online; IIRC (please check this) they list 51 gr IMR-4350 as max w/ 100 gr Noslers which would include the ETip which is stickier than the TSX.
Scott is right on when he suggests letting your chronograph be your guide.
If its any consolation I've been getting 3330 fps from 50.5 gr IMR-4350 & 100 gr Speer HPs for several loadings (>3) without any sign of issues w/ the RP brass in my 24" barreled 257 AI.
Along with the chronograph I like to reload 3 cases and fire them first each time I visit the range just to see how many firings I get before issues arise. Probably overthinking things, but as you say my rifle and especially my face are worth it.
