I shoot no excuses 460 lead conicals out of my .451
They are accurate and both pass through and expand. lung shot deer run regardless, but the blood trails are typical of movie-set quality.
Anything under 150 yards is a layup.
I see very little difference in performance between 60, 70, and 80 grains of 777 3F.
Since they are so heavy, you dont need to worry about pushing max velocity, or vel loss at distance. They WILL penetrate a deer.
Its not flashy, but if you are looking for boring reliability, I'd at least consider trying something along the lines of a full bore all lead conical.