I have a friend with two full-size safes full of rifles. He has everything from the .222 up to the .375 H&H and most everything in between (the .22lr being a given). Whenever he draws a tag, and especially one of semi-importance like bull elk or his once-in-a-lifetime AZ desert sheep tag, he would always reach for his old pre-64 model 70 in .270 Winchester which was always sighted in with the 150gr. Hornady sp. I think for him it all came down to what he was most comfortable with, but if he didn't trust the bullet he wouldn't use it. The Hornady dropped every elk, deer, javelina and pronghorn he shot with it and also helped to fill that sheep tag.
