Old Doe Shooter,
Because of what I do for a living there are way too many different rifle powders in my loading room, well over 50 at last count. But this is also partly because I also have a wide variety of rifles.
Thirty years ago, before I got into writing about handloading, I did all my rifle loading with 3 powders: Unique for reduced loads, IMR4895 for general use, and H4831 for when a slow burner was needed. After a while I added IMR4350 for when H4831 was a little TOO slow, and everything went downhill from there.
If I had to absolutely pare down my list of powders yet keep most of my rifles, I'd ideally want Li'l Gun, IMR4895, TAC, Big Game, H4350, and Magnum. But since severla of those powders are getting hard to find anymore, I'm switching over to IMR4451 from H4350, and subbing IMR7977 for the slower burners like Magnum and Retumbo.
Haven't found a real all-around replacement for Li'l Gun yet, but am searching.
