Personally, I'd go with the Leupold VX-6. I just don't see the NF, given it's weight, knobs, etc as a viable hunting scope for most folks.
The 44mm VX6 weighs 19 ounces, which is the exact same weight as the 42mm NF NXS.
If you like Leupold go with it. Rick C. was on here touting them and then his broke. I had a Mark 4 fail, and that was the last Leupold I bought except for a fixed 4x for a 22LR. All have been sold off except for the fixed 4x and all have been replaced with NF.
I've never had a single problem with a NF and one has many thousands of rounds under it from 7WSM, 308's, 300WM and 338LM's, including hunting.
The 2.5-10x42 NXS Compact is a very nice size, and very durable.
All of the praise for Leupold's customer service is misplaced in my opinion.
The best customer service is to design a product right, build it right, and quality check it before it goes out the door, so that it does not come back. That is excellent customer service.
When the deer of a lifetime is in front of me, I want the scope to work, not a customer service call.
