I shoot the 180 hunting a little over 3100. I have a couple boxes of hybrids but have not tried them yet. The 180s with RL25 in my rifle (7-300win) is an awesome combo.
I have shot mule deer, desert sheep, black bear, and cow elk with the load in the last three seasons; 320 yards to 830 yards.
Ultimately, I do not think terminal performance between the two would be the deciding factor in which to hunt with. If curious try both and go with the load/bullet combo that shoots best at long range with the velocity you want (low ES - least vertical stringing).
Both bullets are going to quickly take care of whatever creature you are shooting.
