The magazine safety on the .22/45 is a pain, but the biggest nuisance is the need to hold down the slide release when dropping the slide on a loaded magazine.
Off topic, but another thing I've noticed with the .22/45 is that it's very fussy about the position of the top round in the magazine. I never had an issue with the standard Mk II Target model I used to have. This one cost me an easy shot at a turkey one fall.
