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I have to disagree. I read his early books too. He recommended 1 gr of powder for every gr of bullet wt. So, a .50 cal PRB was 170gr. He said to use 170gr of powder. A .54 220 gr of powder. He backed off a bit on larger calibers, but the loads were still huge.
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Woa. I took most of my deer this season with a 490 grain .451 conical...
I cant image what a near 500 grain load of BP would be like underneath a 500 grain projectile. Then again, maybe it'd just spit out the unburned powder. I dont intend to find out.