I'm by no means an expert, but I have a DPMS LR243 upper and have an LR260 build. The 243 shoots and functions well, I still have kinks to work out on the 260. Here's what I think I know:
Large frame ARs were designed around the 308, and there are quite a few options for factory rifles and drop in barrels there.
When you get into cartridges that run higher pressure than 308, like 243, 6.5cm, 260 etc you can have issues and kinks that need to be worked out. most of these will be severely over-gassed. Solutions to this range from adjustable gas blocks to heavy buffers and different BCGs. Some of these components are pretty expensive. Could be some headaches for the inexperienced builder.
And I'd guess you'll a minimum of $1000 in a quality built upper alone, plus the lower. All the components for these cost more than ar15 equivalents. But I have noticed Aero Precision running sales with reasonable prices on their M5 receivers, so you might look there.
Also, These riles are very hard on brass IME, if that matters to you.
After messing with them some, I like AR15s better. I'm just breaking in a 6x6.8 upper that is showing promise, and I'm not in any hurry to get the LR243 out...
Last edited by Walter_Sobchak; 10/20/15.