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Originally Posted by slumlord
I am an expert on my present medical condition. I have fired several specialists for glossing over, forgetting and outright overlooking peripheral issues that accompany my situation.

I get tired of having to remind drs to add 1 or more of a dozen appropriate additional labs to even my expanded panels.

I request 5 day holds on cultures beyond the 48 hour.

I have correctly diagnosed an occluded ureter in my transplant TWO times when the neph was pushing me for a biopsy one time. Another time was correlating an outlying parameter within my therapetic drug monitoring lab (which I also insisted upon) Excessive inability for my transplant to clear the anti rejection med is an indication of hydronephrosis, secondary to occlusion.

Every dr I meet wants to know my educational background, my current docs call me a 1%er. I call many shots and they don't resist me now (at least my current team).

When a dr only spends 4 mins with you in an exam room...red flag. Expect baffoonery.
PCP I have just lets me talk. I really have no use for a PCP, it's purely a formality that go for a lab slip for my dna/hla crossmatching monthly draws.

I scope other patients in the waiting rooms and talk with them, I'm astounded at how uninformed and go along to get along they are aka the Turnip Truck patient.



This is exactly the type of responsibility everyone should take in their own health care.


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The true hunter counts his achievement in proportion to the effort involved and the fairness of the sport. Saxton Pope
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Originally Posted by jaguartx
Etoh, the fish oil is an antidote to high chol/triglycerides or to the negative effects of statins?



Both first thru reduced VLDL synthesis in liver, and second by "trafficking" or reducing NEFA (non essential fatty acids) transport to peripheral areas using them as energy source.

energy production in the liver by the lipid pathway is modified when the ratios are off, resulting in excess of the bad stuff. causing and increase in insulin resistance among other things.

CoQ10 and pantothenic acid also help in reestablishing the "energy" required by the muscles and reducing pain, addition of purines help supply that source for ATP also


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Originally Posted by Grumulkin
Originally Posted by papat
Nobody has mentioned big pharmacy pays Docs for prescribing them?


Really? Are you serious?

I don't for a minute deny that big pharma lies to doctors to get them to prescribe things but to pay them would put both parties in jail under federal law.


Big Pharma doesn't lie to anyone, the FDA protocols are very tough for getting a drug ok'd. There are far to many very informed "specialists" in the various fields to float bullshit past them.

The problem arises simply do to the lack of knowledge across the board. A new drug comes out, gets used by a large enough statistical sampling to provide evidence, new pathways are developed more new medicine.


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Originally Posted by wabigoon
I have a bigger complaint with the blood pressure medications I take.



Because it is very difficult to assign a specific pharmacological cause-effect relationship between a medicine and the event, the concept of single entity drugs became popular in the late 60s and dominates medical practice protocol.

This means if a practitioner gives a blood pressure med, they want to see the pressure drop, right now, and by a predictable amount.

This takes a very "strong" drug in the sense it will be working on many other organs in the body. The question then becomes one of "therapeutic range". At what dose level will the side effects become such that the med represents more of a hazard than a medicine.

(all drugs, medicines are Poisons)


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Originally Posted by Paddler



What a bullshit article. 20% of all adolescence in US are pre-diabetic caused by the time frame when Obama was in office


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How about 4 months no bp meds, and I was 123/76 just now, and my morning sugar was a 93 !
Diet, excercise, and weight loss.
By God, I'm going to live forever !!

3 months, and 1 week to go, as per my doc to be released to go back to work from back surgery !!

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Originally Posted by hatari
If you can tolerate them, there is a mountain of evidence that they are cardio protective.



If it hasn't yet been said, Statins likely provide cardiovascular protective effects independent of their LDL-lowering effects.


https://www.ahajournals.org/doi/full/10.1161/circresaha.116.308537



Last edited by night_owl; 12/04/19.


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Originally Posted by hatari
Originally Posted by The_Real_Hawkeye

My dad and mom used to get taken out to the finest restaurants for three pound lobsters and such by drug reps back in the day. Yeah, they outlawed this practice some years ago.



And let's acknowledge that most of that drug rep smoozing was "use our __________ (fill in your category of drug i.e Beta Blocker, statin. brand of hydrocodone, etc.) instead of Brand X". In otherwords, the drug version of "Buy a Silverado instead of a F-150". Both are trucks. Lobster was to get them to like the Chevy and recommend that over the Ford.


Luckily, Alcon had the best eye disease drugs. It is disturbing that getting the govt to pay for certain drugs on Medicare plans effectively shuts other great drugs out of the market and doomed or at least relegated to the back shelf. Insurance companies are the same. If they dont cover the best drug its screwed

Palms are greased in Govt and Ins companies. There ought to be a law.


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The post below is state of the art for 1978 but completely wrong today. Some studies show either no benefit from taking statins, while others show an extremely small benefit. The lipid-heart hypothesis has been completely debunked. Inflammation caused by eating processed foods is what causes heart disease, not cholesterol. And recent studies show a strong connection between higher cholesterol levels and longer life. No study has shown causation between cholesterol levels and coronary artery disease, but causation has been shown between inflammation and coronary artery disease. Since the McGovern report (early 1980s), the government and the medical profession have been giving us not just bad advice for 40 years, but absolutely harmful advice.

Here is some support for those who still believe the lipid-heart lie:

https://www.youtube.com/watch?v=inwfSkSGvQw

https://www.youtube.com/watch?v=YpllomiDMX0




Originally Posted by Grumulkin
Just a few thoughts...

1. The advice to take a statin is based on statistics that indicate levels of risk. It's true people are individuals and not everyone with a high cholesterol will die of a heart attack or stroke, statistics indicate when there is more of a risk in not being treated than in being treated. If you feel lucky, make your own stuff up.

2. For the guy with a 14% chance of a "heart episode" in the next 15 years who is OK with that, I say you'll rethink that if said episode happens. That is if you're still alive and thinking.

3. If your doctor doesn't recommend standard therapy, guess who will be blamed when you have the big one?

4. I presume your wife has some sort of medical background and is qualified to recommend "additional tests" and a "Coronary CT scan." Carefully consider this. If the CT scan shows coronary artery calcification does that mean you will take a statin? If the CT scan is fine, does than mean you won't have a heart attack? It should be of some consolation to you that since you're 68, the radiation from the CT scan is extremely unlikely to initiate cancer in your lifetime.

5. And finally, did you know that lifestyle modification can prevent and even reverse coronary artery disease? That would mean no smoking and an entirely plant based diet and for those with a severe problem, no fats or oils. Maybe that's too much. Probably easier to have bypass surgery.

By the way, I don't take a statin and wouldn't want to. My doctor recommend I take an aspirin daily and I declined. My risk of having a heart attack is exceedingly small since my total cholesterol is always less than 140 so I don't need a statin. I would have more of a risk of bleeding from the aspirin than my risk of a stroke or heart attack without it. Oh, I must add, I've been a vegetarian for the last 50 years.

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I recently had a minor heart attack while working out at the gym. At 58 I was fit, active and had little reason to expect trouble. The only clouds on the horizon were a history of living and working with heavy smokers, low HDL and some distant family history of heart disease. I ignored those signals and that did not work out too well for me … nor will it work out for those of you reading this who are prone to wishful thinking.

This forum is the wrong place to seek advice on health issues (or any other issue for that matter). Seek out qualified health professionals and listen to them.

I speak from experience when I say that a quad bypass surgery will get your attention.


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Originally Posted by Etoh
Originally Posted by Grumulkin
Originally Posted by papat
Nobody has mentioned big pharmacy pays Docs for prescribing them?


Really? Are you serious?

I don't for a minute deny that big pharma lies to doctors to get them to prescribe things but to pay them would put both parties in jail under federal law.


Big Pharma doesn't lie to anyone, the FDA protocols are very tough for getting a drug ok'd. There are far to many very informed "specialists" in the various fields to float bullshit past them.

The problem arises simply do to the lack of knowledge across the board. A new drug comes out, gets used by a large enough statistical sampling to provide evidence, new pathways are developed more new medicine.


Yea, Big Pharma does lie to physicians like when they said Oxycontin wasn't that addictive. Maybe you didn't get that news. Then there was the Flexeril affair. Flexeril was about to go off patent; that is the dosage form of 10 mg three times daily. Suddenly the drug company came out with a new dosage form; 5 mg three times daily which they said would work just as well with less sedation and thus extended their patent. But wait, it gets better. When asked, why couldn't a patient just cut the cheaper 10 mg tablet in half, the drug rep said that wouldn't be safe because one half of the tablet might have more Flexeril in it than the other half.

And I could go on.

In my opinion all drugs are poisons but sometimes, perhaps from poor lifestyle choices, they're needed. I would rather eliminate poor habits and thus save money and my health.

There is a saying, "the newest drug has the fewest side effects."

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Originally Posted by night_owl
Originally Posted by hatari
If you can tolerate them, there is a mountain of evidence that they are cardio protective.



If it hasn't yet been said, Statins likely provide cardiovascular protective effects independent of their LDL-lowering effects.


https://www.ahajournals.org/doi/full/10.1161/circresaha.116.308537




yes brought up in the 2nd really long thread awhile back. anti-inflammatory effects reducing dementia


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Originally Posted by 500grains

The post below is state of the art for 1978 but completely wrong today. Some studies show either no benefit from taking statins, while others show an extremely small benefit. The lipid-heart hypothesis has been completely debunked. Inflammation caused by eating processed foods is what causes heart disease, not cholesterol. And recent studies show a strong connection between higher cholesterol levels and longer life. No study has shown causation between cholesterol levels and coronary artery disease, but causation has been shown between inflammation and coronary artery disease. Since the McGovern report (early 1980s), the government and the medical profession have been giving us not just bad advice for 40 years, but absolutely harmful advice.

Here is some support for those who still believe the lipid-heart lie:

https://www.youtube.com/watch?v=inwfSkSGvQw

https://www.youtube.com/watch?v=YpllomiDMX0




Originally Posted by Grumulkin
Just a few thoughts...

1. The advice to take a statin is based on statistics that indicate levels of risk. It's true people are individuals and not everyone with a high cholesterol will die of a heart attack or stroke, statistics indicate when there is more of a risk in not being treated than in being treated. If you feel lucky, make your own stuff up.

2. For the guy with a 14% chance of a "heart episode" in the next 15 years who is OK with that, I say you'll rethink that if said episode happens. That is if you're still alive and thinking.

3. If your doctor doesn't recommend standard therapy, guess who will be blamed when you have the big one?

4. I presume your wife has some sort of medical background and is qualified to recommend "additional tests" and a "Coronary CT scan." Carefully consider this. If the CT scan shows coronary artery calcification does that mean you will take a statin? If the CT scan is fine, does than mean you won't have a heart attack? It should be of some consolation to you that since you're 68, the radiation from the CT scan is extremely unlikely to initiate cancer in your lifetime.

5. And finally, did you know that lifestyle modification can prevent and even reverse coronary artery disease? That would mean no smoking and an entirely plant based diet and for those with a severe problem, no fats or oils. Maybe that's too much. Probably easier to have bypass surgery.

By the way, I don't take a statin and wouldn't want to. My doctor recommend I take an aspirin daily and I declined. My risk of having a heart attack is exceedingly small since my total cholesterol is always less than 140 so I don't need a statin. I would have more of a risk of bleeding from the aspirin than my risk of a stroke or heart attack without it. Oh, I must add, I've been a vegetarian for the last 50 years.





Could go with a lengthy on Statics, and the references in NCBI, and PLOS but I think it would be a waste of time.


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Originally Posted by Paddler



In one of your former incarnations (before you started sharing this account), "Paddler" *was* a physician. Now you quote the NY Times?
Credibility gap here is "incredible".


"The Democrat Party looks like Titanic survivors. Partying and celebrating one moment, and huddled in lifeboats freezing the next". Hatari 2017

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Originally Posted by Grumulkin
Originally Posted by Etoh
Originally Posted by Grumulkin
Originally Posted by papat
Nobody has mentioned big pharmacy pays Docs for prescribing them?


Really? Are you serious?

I don't for a minute deny that big pharma lies to doctors to get them to prescribe things but to pay them would put both parties in jail under federal law.


Big Pharma doesn't lie to anyone, the FDA protocols are very tough for getting a drug ok'd. There are far to many very informed "specialists" in the various fields to float bullshit past them.

The problem arises simply do to the lack of knowledge across the board. A new drug comes out, gets used by a large enough statistical sampling to provide evidence, new pathways are developed more new medicine.


Yea, Big Pharma does lie to physicians like when they said Oxycontin wasn't that addictive. Maybe you didn't get that news. Then there was the Flexeril affair. Flexeril was about to go off patent; that is the dosage form of 10 mg three times daily. Suddenly the drug company came out with a new dosage form; 5 mg three times daily which they said would work just as well with less sedation and thus extended their patent. But wait, it gets better. When asked, why couldn't a patient just cut the cheaper 10 mg tablet in half, the drug rep said that wouldn't be safe because one half of the tablet might have more Flexeril in it than the other half.

And I could go on.

In my opinion all drugs are poisons but sometimes, perhaps from poor lifestyle choices, they're needed. I would rather eliminate poor habits and thus save money and my health.

There is a saying, "the newest drug has the fewest side effects."


you obviously didn't get the news. Pharm has never said Oxy was not addicting. Its the diversion of the drug from legitimate channels that is causing the problem. (even then its not as insidious as drug cartels)

Please quote name of drug rep, yea thats what I thought.
The reason tablets are not recommended to be cut is in their manufacture the pressure used to make the tablet also makes it difficult to cut, they usually shatter or cut unevenly. if the mg base of the drug is high say around 100 mg the amount lost in curmbled powder is insignificant. if small as in the case Flexeril it matters.

Im sure you could go on. but it is good that you have put some thought into it.


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Originally Posted by hatari
Originally Posted by Paddler



In one of your former incarnations (before you started sharing this account), "Paddler" *was* a physician. Now you quote the NY Times?
Credibility gap here is "incredible".



Yes

why no quotes or reference from peer group evaluation sites?


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Whoever Paddler is (*are* - probably shared account), he is no medico as once claimed.

His bullschitt article from Paul Krugman (of all people) about Red State mortality has a very simple demographic expalination that has nothing to do with politics. African Americans have a high rate of heart disease and diabetes. SInce the South is composed of Red States, all you do is need to do is look at a graphic that shows county by county morbidity and mortality from those two diseases and you will have no problem picking out the old cotton belt from Virginia south and west right into Louisiana. You can talk about poverty all you want, but singularly the most important demographic factor is that those areas are predominatly African American. Diet, exercise and genetic predisposition covers most of that ground.


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Originally Posted by Etoh
Originally Posted by Grumulkin
Originally Posted by Etoh
Originally Posted by Grumulkin
Originally Posted by papat
Nobody has mentioned big pharmacy pays Docs for prescribing them?


Really? Are you serious?

I don't for a minute deny that big pharma lies to doctors to get them to prescribe things but to pay them would put both parties in jail under federal law.


Big Pharma doesn't lie to anyone, the FDA protocols are very tough for getting a drug ok'd. There are far to many very informed "specialists" in the various fields to float bullshit past them.

The problem arises simply do to the lack of knowledge across the board. A new drug comes out, gets used by a large enough statistical sampling to provide evidence, new pathways are developed more new medicine.


Yea, Big Pharma does lie to physicians like when they said Oxycontin wasn't that addictive. Maybe you didn't get that news. Then there was the Flexeril affair. Flexeril was about to go off patent; that is the dosage form of 10 mg three times daily. Suddenly the drug company came out with a new dosage form; 5 mg three times daily which they said would work just as well with less sedation and thus extended their patent. But wait, it gets better. When asked, why couldn't a patient just cut the cheaper 10 mg tablet in half, the drug rep said that wouldn't be safe because one half of the tablet might have more Flexeril in it than the other half.

And I could go on.

In my opinion all drugs are poisons but sometimes, perhaps from poor lifestyle choices, they're needed. I would rather eliminate poor habits and thus save money and my health.

There is a saying, "the newest drug has the fewest side effects."


you obviously didn't get the news. Pharm has never said Oxy was not addicting. Its the diversion of the drug from legitimate channels that is causing the problem. (even then its not as insidious as drug cartels)

Please quote name of drug rep, yea thats what I thought.
The reason tablets are not recommended to be cut is in their manufacture the pressure used to make the tablet also makes it difficult to cut, they usually shatter or cut unevenly. if the mg base of the drug is high say around 100 mg the amount lost in curmbled powder is insignificant. if small as in the case Flexeril it matters.

Im sure you could go on. but it is good that you have put some thought into it.


Dear Sir:

Here is current news from the Florida Medical Association:

"However, in 1996 the American Pain Society trademarked the slogan, “Pain: The Fifth Vital Sign,” and we then saw OxyContin® released by Purdue Pharma. In the late 1990s, pharmaceutical companies continued to reassure the medical community that patients would not become addicted to opioid pain relievers. This resulted in increased prescribing of opioid medications, leading to widespread misuse of both prescription and non-prescription opioids before it became clear that these medications could be highly addictive in many individuals."

And you really expect me to remember the name of the drug rep that spoke on Flexeril probably around 2014? You flatter me. As for not being able to cut a 10 mg Flexeril tablet in half, I'll bet around 99.99% of those on the Campfire would be able to figure out how to do it.

Then here is part of a blurb from the 9/11/19 issue of The Washington Post:

"Purdue Pharma, manufacturer of the blockbuster painkiller OxyContin, reached a tentative settlement Wednesday with 23 states and more than 2,000 cities and counties that sued the company over its role in the opioid crisis, according to attorneys involved in the deal."

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Way off topic but answering some of this to show how shiit gets put in the wrong pigeon holes .


ridiculous article, morphine alkaloids have always been known to be addictive. They also have a very low side effect profile compared to --- oh what hmmm shall we say statins.


on the rep, you said he said nothing but here say.

tablets are not recommended to be divided unless they are scored by the entire dispensing community Ok tell me you have a Class A prescription balance or an analytical balance or the members here could just weigh it on their powder scales.
hint. cutting of tablets in the micro milligram range would cause death.

oxycodone is produced by many makers and generic drug makers, by the tons and still is. how come they aren't included in the law suit?

The reason is because schedule II drugs have their own forms for ordering with multiple copies, one goes to DEA, one to wholesaler or maker, one is kept. one is made into paper airplane (just kidding)

maker is required to notify DEA when unusual amounts are order from one source. the dispensers in Tennessee, (which has different laws than the rest of country on mail order drugs). Purdue was found negligent and the rest of the pharmacies and docs. in Tennessee got off because they had their ducks inline.


also all states require month end down loads of all schedule drugs dispensed, to compare for "shoppers" this was not started until about 2010,


for every "Blockbuster Oxycontin" used or dispensed their are 10 Lortab, or 10 times as many nontime release oxycodone used.


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