I replaced Unique with TiteGroup many years ago.
I just ordered a pound of Titegroup this morning to try in an extremely finicky 45 Colt rifle. It's one of the only things I've owned I couldn't get to shoot Unique well.
The only powder it has responded very well to so far is Trail Boss, and the trajectory with that load is like a fuggin rainbow for shooting 100yd plates. It shoots 244 Win and Nitro 100NF ok, but there are some pressure signs I'm not liking with 244, and the Nitro100 velocity is about identical to the TB loads.
All the other powders I had on hand shot like garbage in it... definitely the pickiest 45 Colt I've owned.