Hey Ricky,
I run hornady 300xtp's mmp short black sabots with AA 5744, 44gr charge or lee dipper 3.4cc shaken level. It's a pretty standard load for savages and I can see why. It's kept me in pepperetts and steaks for a few years now.
I had a spectacular kill last season with this load. Our crew got set up early on a island of bush and I blocked one side. After awhile I hear a truck easing up a gravel road behind me a couple hundered yards. Looked around the ancient hydro pole I was leaning on and yep lots of orange in there. Pressures on now looks like I got an audiance.
Just then the sound of twigs snappen in front of me. Three does bust out wide open. Got on the last one swinging a lead about the base of her neck and letter hang. Deer went up in the air did a complete somersault landed on her back stone dead not even a twitch! On the 60 paces to her I got some fist pumping thumbs up from the peanut gallery, at least I think thats what it was. They may have been flippin' me off for being there first.
Bullet hit behind shoulder destoyed lungs, broke spine removing the bottom of some vertabre and lodge on off side hide. It wieghed 209gr impact velocity 2000fps I would guess, and doe wieghed 120#. Not bad for a pistol bullet. The enerergy transfer on deer is ammazing. I'm actually marinating on of her shoulders right now
If I were to run 250's I would start with this powder and charge and work up a bit maybe to play around with accuracy. A friend uses it the 3.4cc lee dipper and my AA5744 (buy your own Trav) with a 250gr bullet in his savage and it's worked well for him.
AA5744 measures easy, ignites easy is all around very forgiving double based powder. It has a 20% nitroglycerin content which gives it a glazed look. This glazing makes this powder less hydroscopic than say imr 4759 or n110. Good for those rainy hunts.
I have not tried n110 but I've heard it can shine with 250's.