I killed a 1000,lb cow, with a 86 Win. 1901, with the rem 405s, but I was like 50yrds, 2 shots in the lungs, broad side! went 60 -70yrds, killed a 400lb Black bear, same rem 405s 30yrds, went in top of the neck, thru the body out a hind quarters! slow but powerful!