I run the Win/Nosler Combined Technology slugs (mollied 180's) through an Accumark. A load of 120 grains of H870 (can't get it anymore) was worked up and used in winter months with a velocity just a hair under 3,500 fps. Worked just fine on moose, caribou and elk.
Took everything out for a preseason check in some 90+ degree F temps and got some stiff bolt lift. With little time at hand, I pulled my slugs, dumped 2 grains of powder, put things together, rechecked zero, and headed out to hunt. I've not had a chance to chrony it with the reduced load, but it still shot little tiny bug holes at 100 yds. One of the most accurate units I own, and it will reach well across canyons to touch elk.