I've used quite a few 165 Gamekings on deer out of an '06 and they do a good job of killing. They also do an excellent job of blood shooting meat. I like Federal Gold Medal large rifle primers and RL19: 61 grains if memory serves. That's max or nearly so, so work up to that recipe if you choose to try it. It's a fast load but I haven't had any issues with the bullets coming apart as evidenced by one large exit would, but I can't remember taking out a shoulder either.