captdavid...
I dont' know what your application is. But, some load I use are the following:
59-60grs of H4831, 154 Hornady Interlocks, WLR primers, Rem Brass.
60-61grs of R-22, (rest the same)
60-61grs of VV-N165 (rest the same)
Each of those loads produced 2990-3030fps in a 24" bbl Rem 700. And have duplicated near same velocity with Nosler Solid Bases and same loads.
Id ditch the 4350 for bullets over 140grs in the .280 if velocity is a concern.