I've only used the .338 185's lately. Took a bull elk at 186yds, and caught the bullet after 3' of penetration. Another bull at 700yds, and bullet broke onside shoulder, souped lungs, and exited. 2 deer at 400+, both exits, both shoulders broken, vitals souped. I was pretty concerned about their performance when impact velocity dropped off but they seem to do pretty good even at low speeds.
