Of those listed below, I would go with the 300 gr Nosler Partition.
My own personal choice would be the 270 gr TSX for all larger things North American. Works exceedingly well on moose and have confidence that it would work as well on large bear.
Probably not many wrong answers with a 375 H&H and any decently constructed bullet that shoots well in your rifle.
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Originally Posted by GuyM
I've taken three black bear with my .375 H&H, each with a 260 gr Nosler Accubond. Am happy with the performance of that bullet, and it is very accurate too.

Looks like I may have the opportunity to hunt grizzly/brown bear in the not-too-distant future.

I'm a handloader, and have accumulated quite a stash of .375" bullets. Trying to pick one for that hunt.

260 Nosler Accubonds - have a few left - and am happy with them
270 Nosler Partitions - the old screw machine bullets - have about 150
300 Nosler Partitions - some old, some new - have about 200

285 Speer Grand Slam - have fewer than 50

270 Hornady Round Nose - about 100
270 Hornady Spire Point - about 100
300 Hornady SPBT - about 200 (also very accurate from my rifle)
300 Hornady Round Nose - about 100

Any bad choices there?

Thanks, Guy