Ts300wsm: Back in 1986 I had a custom Rifle built in 280 Remington caliber.
Since then I have killed Mt. Goat, Blacktailed Deer, Antelope, Mule Deer, Black Bear, Whitetailed Deer and Bull Elk with it - so far.
Someday I will kill a Caribou with this wonderful cartridge/Rifle combination.
My 280 has a 25" Douglas Supreme medium weight barrel on a pre-64 Winchester Model 70 action in a McMillan fiberglass stock.
This Rifle is accurate and very reliable - it also is very lethal on medium size Big Game!
I use the wonderful Nosler 140 grain Partitions in my Rifle and have since day one - so no experience with the Nosler 150's.
If I ever get a Bighorn Sheep tag this is THE Rifle I will use.
The only two shot kill I can remember with this Rifle/cartridge was on a running Bull Elk that I "led" way to much.
My first shot struck that nifty Bull in the nose (I still feel bad about that!) but it stopped him in his tracks and my second shot was right through the heart/lungs and that was that.
All my other kills were one shotters as I recall.
I hope you have as good luck with your 280 as I have had with mine.
Hold into the wind
VarmintGuy
