I can only speak from my experience.

Some of the early slow-twist .250s will shoot 100 grain bullets, but some will not.

The Speer 87 grain Hot Core is a sure fire bet and a good bullet. May be hard to find but worth the search. Mine like 33.5 grains of 3031 behind them and a CCI BR2 primer. Usual benchrest prep.

This load delivers 1-1/4" groups from the bench at 100 yards for three shots. That is with a Marble's tang peep and gold bead. Target is a giant 1" wide black cross across a day-glo piece of poster paper. Makes a "cross hair" behind the bead. Try it sometime.

If you need a 100 grainer, others will have advice.

Best wishes, Marc