HuntAlaska--
You really ought to go back and read JJHack's threads about bullet choice. His experience probably exceeds the total experience of everyone on this thread added together.
He really likes pass-throughs for blood trail.
And don't forget that once you poke a hole in an animal, you have bought it. So the trophy fee on a a kudu could easily be $1500. I found that generated a lot of mental pressure. Would you go to a local turkey shoot and bet $1500 on the outcome of a single shot? That is why I err on the side of heavier bullets and/or bigger calibers, just to put the odds in my favor.
I'll bet the 140 TTSX will work great for you, for the animals you listed. But like many of the other posters on this thread, I would tend to go heavier.
But do a lot of practice from a standing tripod--that will contribute more to your success than obsessing over bullet gack.
