I used 220 on Idaho elk about 35 years ago. I am 4 other friends all used them. I loaded Hornady and a one box of Sierras. I can't remember any of my friends ever saying a bad thing abut them on elk, deer or bear and also 1 moose. There were 5 of us using the ammo I loaded. This went on for about 6 years. The 220s work great. Just a big fairly soft bullet at about 2500 FPS from the muzzle.
My friend Pete also killed a bison with one.
Nothing remarkable to report, but no failures at all. I know Pete recovered his bullet from the off-side of the buff under the hide. I don't remember anyone else recovering one from any animal. I never did.
Just a nice exit on everything and good sized wound channels about 1.5" around
