Well, funny as it may seem, I have actually killed deer with 458s and 460s both. Why?
Why not?
You will find that most bullets made for the 458 will not expand at all on deer, so they are killed without much blood shot meat. it also doesn't drop them on the spot in most cases, but lets them run a short way.
The other option is to use bullets that were made for the 45-70 and reduce their speed a bit from full throttle. If you run them too fast they are "too soft". If you run them at full speed the wound channels are REALLY large and dramatic.
I found the best load was a 500 grain LBT style hard cast gas-checked bullet loaded at "only" 1800 FPS. In my 2 458s I owned then, both would hold this at about 1.25" at 100 yards. Hits on deer would kill a bit faster than the round nosed jacketed bullets. Keep in mind that a45 colt with a heavy round nose bullet works OK on deer, so increasing the bullet weight 250 grains and the velocity 2X can't make it worse.
