It has been my experience with Barnes bullets that the best accuracy comes when pushing them to near max velocity. I've experienced this in several different rifles and calibers.
With that being said, a few years ago I worked up an accurate load using the 80 gr TTSX using 46.8 gr Ramshot Hunter for ~3415 fps. Since then, the multiple deer, antelope, hogs and coyotes haven't complained once.
Good luck!
