My 2 cents, No downside, irregardless of powder choice. This caliber has proven to be one of the easiest to get along with, in that it seems difficult to find reasonable combinations that don't work.
Imagine your grave on a windy winter night. You've been dead for 70 years. It's been 50 since a visitor last paused at your tombstone..... Now explain why you're in a pissy mood today.
