Go to
www.riflesandrecipes.com, pay the $8 for a subscription to Rifle Looney News and you'll not only get the current issue, but access to ALL of the back issues - for a cheapskate like me, it's the deal of the decade!
Anyway, RLN33 (Feb 2017) has an article called "Set and Forget Scopes", that details using a plex reticle for up to 500 yard shots - no turret twisting - with a fixed 6x scope! It will answer all of your questions with details provided by someone who has been there, done that.